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Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

Kidney Diseases Clinical Trial

Official title:
Epidemiology of Chinese Herb Nephropathy and Its Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

Clinical Trial Summary

1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA).

2. AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer

3. Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN.

4. By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.

Clinical Trial Description

n/a

Study Design

Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01503645
Study type Observational
Source National Taiwan University Hospital
Contact Fe-Lin L Wu, Ph.D.
Phone +886-2-23938231
Email flwu@ha.mc.ntu.edu.tw
Status Recruiting
Phase N/A
Start date May 2006
View Details
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