Liver Diseases Clinical Trial
Official title:
Analysis of Volatile Organic Compounds in Exhaled Air as a Non-invasive Biomarker for Liver Diseases
Liver diseases such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease
(ALD) and viral hepatitis have the potential to progress to cirrhosis and finally
hepatocellular carcinoma (HCC). Early diagnosis and treatment of liver diseases is important
since progression is likely and is associated with significant morbidity and mortality.
However, in daily clinical practice no specific and non-invasive biomarkers are used for the
diagnosis and follow-up of patients with liver diseases. It is known that patients with
liver diseases produce compounds that can be excreted in breath as a consequence of
metabolic processes, inflammation and/or oxidative stress. These are called volatile organic
compounds (VOCs). Analysis of VOCs in exhaled air has been reported to provide valuable
information in patients with chronic obstructive lung disease (COPD) and inflammatory bowel
disease (IBD). Also, in patients with liver disease, exhaled VOCs have been detected.
The investigators hypothesize that analysis of VOCs in exhaled air of patients with liver
diseases can be used for diagnosis and follow-up.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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