Acute Respiratory Distress Syndrome Clinical Trial
Official title:
Genetic Variability and Biomarkers in Children With Acute Lung Injury
Acute Lung Injury (ALI) and the more severe Acute Respiratory Distress Syndrome (ARDS) are a
significant problem in Pediatric Intensive Care Units, affecting up to 16 of every 1000
children admitted to these units. These disorders carry with them high mortality rates as
well as numerous long-term effects for the surviving children. As the effects of these
diseases have significant social and economic ramifications for affected children and their
families, research on the development of ALI/ARDS could significantly change how physicians
understand the disease and treat patients.
There are a wide range of problems which make certain PICU patients more likely to develop
either ALI or ARDS. This research aims to determine which of these children are at the
greatest risk for ALI/ARDS by examining differences in plasma biomarkers and in DNA of a
large number of PICU patients. We are hypothesizing that significant differences in the
level of specific plasma biomarkers or in the frequency of specific DNA variants exist in
children who develop ALI/ARDS.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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