Brain and Central Nervous System Tumors Clinical Trial
Official title:
A Phase II, Multicenter, Study for Newly Diagnosed Glioblastomas Using Boron Neutron Capture Therapy, Additional X-ray Treatment and Chemotherapy
RATIONALE: Boron neutron capture therapy and radiation therapy use high-energy x-rays and
other types of radiation to kill tumor cells. Drugs used in chemotherapy, such as
temozolomide, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Giving boron neutron capture therapy followed by
radiation therapy and temozolomide may kill more tumor cells.
PURPOSE: This phase II trial is studying the side effects of giving boron neutron capture
therapy together with radiation therapy and temozolomide in treating patients with newly
diagnosed glioblastoma multiforme.
OBJECTIVES:
- Evaluate the overall survival of patients with newly diagnosed glioblastoma multiforme
treated with boron neutron capture therapy, radiotherapy, and concurrent and adjuvant
temozolomide.
- Evaluate tumor response in patients treated with this regimen.
- Evaluate the adverse effects of this regimen in these patients.
OUTLINE: This is a multicenter study.
Patients undergo boron neutron capture therapy followed by radiotherapy and concurrent and
adjuvant oral temozolomide.
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