Multiple Myeloma and Plasma Cell Neoplasm Clinical Trial
Official title:
Screening of Cathepsin G Levels in Multiple Myeloma Patients Receiving Treatment With Thalidomide/Lenalidomide Within the ECOG Trials E1A00 and E4A03
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research study is looking at blood samples from patients with multiple myeloma
who were treated with thalidomide or lenalidomide.
OBJECTIVES:
Primary
- To analyze the mechanism of development of thalidomide/lenalidomide-induced venous
thromboembolism (VTE) in patients with multiple myeloma treated on clinical trial
ECOG-E4A03 or E-E1A00.
- To determine the intensity, dynamics, and specificity of cathepsin G (CG) upregulation
in response to thalidomide and lenalidomide treatment.
- To determine the specificity and threshold levels of CG for induction of platelet
aggregation in response to thalidomide and lenalidomide and the resulting risk for VTE
development.
OUTLINE: Blood samples obtained before, during, and after treatment with thalidomide or
lenalidomide from patients previously enrolled on clinical trial ECOG-E4A03 or E-E1A00 are
analyzed to determine the total content of cathepsin G (CG) via ELISA; to determine mRNA
levels of CG via RT-PCR; and for platelet aggregation studies. Blood samples are collected
from healthy volunteers for platelet preparation.
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