Gastroesophageal Junction Adenocarcinoma Clinical Trial
Official title:
Phase II Study of Neoadjuvant Taxotere, Cisplatin, and 5-Fluorouracil in Patients With Gastric or Gastroesophageal Junction Adenocarcinoma
The primary purpose of the study is to determine the impact of chemotherapy on the ability
of your surgeon to completely remove the cancer as well as the impact on your survival.
Furthermore the investigators will be assessing the side effects of this chemotherapy
strategy. Finally the investigators will determine the ability of specialized imaging
technology (PET scan) to document and predict the response of the tumor to this
chemotherapy.
Standard therapy for patients with your condition usually consists of surgery (removal of
the tumor) followed by combination chemotherapy and radiotherapy. More recently, standard
options available to patients with cancer of the stomach or lower esophagus have been
expanded to include chemotherapy without radiotherapy prior to and following surgery. While
it is believed that chemotherapy prior to surgery is a good option for patients with
stomach, it is not known what is the optimal chemotherapy regimen to offer patients prior to
surgery to improve the likelihood of cure while limiting side-effects to patients.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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