Proliferative Diabetic Retinopathy Clinical Trial
Official title:
Efficacy Study of Pre- and Intra-operative Intravitreal Bevacizumab Injection on Postoperative Vitreous Hemorrhage After Diabetic Vitrectomy
The purpose of this study is to determine the effect of pre- and intra-operative bevacizumab injection on postoperative vitreous hemorrhage after diabetic vitrectomy.
Postoperative vitreous hemorrhage(VH) is a common complication after vitrectomy for
proliferative diabetic retinopathy. Persistent or recurrent VH can delay visual
rehabilitation and give patients much trouble. There have been efforts to lower the
incidence of postoperative VH such as using intraoperative gas tamponade and preoperative
bevacizumab injection. Bevacizumab(Avastin) is a potent inhibitor of angiogenesis and has
been shown to decrease retinal and iris neovascularization in proliferative diabetic
retinopathy. Recently there have been reports showing that preoperative intravitreal
bevacizumab (IVB) injection could reduce intraoperative bleeding from abnormal vessels and
could make surgery easier and more successful.Our hypothesis is that preoperative
bevacizumab injection could reduce postoperative VH by way of decreasing the amount of
abnormal vessels and intraoperative injection could also reduce postoperative VH by
inhibiting the vessel formation after surgery.
To prove our hypothesis, we started the prospective randomized comparative study to
determine the effect of pre- and intra-operative IVB injection on postoperative vitreous
hemorrhage after diabetic vitrectomy.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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