Ureteral Calculi, Hyperalgic, Not Complicated Clinical Trial
Official title:
Interest of Néfopam in the Treatment of Pain During the Intense Ureteral Calculi Uncomplicated in Adults in Emergencies Unit.
The administration of néfopam after initial treatment by kétoproféne, could obtain, in
patients remaining pain and classically need morphine, analgesia at least the same as
morphine alone. The use of néfopam second line after ketoprofen could reducing (or even
eliminating) the need for morphine (and its side effects), allowing a reduction in the
length of stay of patients in the emergency unit.
The main objective is to show that the addition of a néfopam initial treatment with the
kétoproféne, reduces, in patients with ureteral calculi, the percentage of patients
requiring the use of a treatment by morphine.
The secondary objective is to reduce the side effects caused by the morphine, shorten the
time to install the appropriate level of analgesia while reducing the risk of failure of the
titration morphine, reduce the time spent on titration of morphine and reduce the length of
stay patient intake in emergency unit.
The study is prospective, parallel, double-blind, randomized, placebo-controlled analysis
with intent to treat. There are 2 groups:
- A group N: néfopam
- A group P: placebo And all the patient receive, before randomization, 100 mg of
ketoprofen (Profenid ®) on 20 minutes.
The number of subjects is 52.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment