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Inhibition of Aldosterone in Patients With Chronic Renal Disease

Kidney Failure, Chronic Clinical Trial

Official title:
The Effect of Aldosterone Inhibition on Proteinuria in Patients With Progressive Renal Disease

Clinical Trial Summary

The purpose of this study is to examine whether the inhibition of aldosterone will result in lower excretion of protein via urine. The hypothesis is that if loss of protein is lowered, progression of renal disease with be slower than otherwise expected.

Clinical Trial Description

Patients with chronic renal disease are likely to progress to end stage renal disease with the need for renal replacement therapy. It is accepted that proteinuria is a surrogate measurement for progression. If proteinuria can be lowered we hope to prolong patients pre-dialysis phase. Our theory is that aldosterone inhibition will lead to this.

For a period of 8 weeks patients will be randomized to either aldosterone receptor inhibition with the drug eplerenone or control without. Blood pressures will be kept at the same level using other drugs. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00430924
Study type Interventional
Source Herlev Hospital
Contact
Status Completed
Phase Phase 4
Start date March 2007
Completion date August 2009
View Details
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