Antidepressant Induced Excessive Sweating Clinical Trial
Official title:
A Pilot Study of the Efficacy and Tolerability of Terazosin for the Treatment of Antidepressant-Induced Excessive Sweating
This study is based on the hypothesis that terazosin, a blocker of alpha-1 receptors, will be effective in reducing excessive sweating caused by antidepressant treatment, and will have minimal adverse effects.
Sweating is a common and bothersome side effect of treatment with antidepressants. Most or
all antidepressants have been clearly shown to cause excessive sweating. It is unclear to
what extent excessive sweating caused by antidepressants becomes less or goes away with
time. In many instances, it continues to be a problem even after 6 or more months on the
antidepressant.
There is no generally accepted treatment for excessive sweating. This study has been
designed to study whether terazosin is effective in reducing antidepressant-induced
sweating, and whether it is well-tolerated and acceptable to patients. In addition,
secondary objectives of this study are to determine the time taken for patients to respond
to terazosin, the usual doses needed for improvement, and the extent of reduction in
sweating. This information will not only help doctors in using terazosin for this purpose in
their patients, but will help in designing further studies of this treatment.
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Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment