Kidney Failure, Acute Clinical Trial
Official title:
Study of Heat Shock Proteins as Prognostic Factor of Acute Renal Failure in Children (HSP-Study)
The purpose of the investigators' study is to determine whether the production of heat shock proteins has an effect on the development and the outcome of acute renal failure in children.
A prognostic factor for the development of acute renal failure (ANR) in children would be
very valuable for therapy regulation. So-called chaperones out of the family of heat shock
proteins (HSP) are promising candidates which are involved in the development of ANR as
well. This could be a starting point for the development of new therapeutic approaches.
ANR occurs in up to 50 percent of all critical ill patients and has a high rate of morbidity
and mortality despite advances in symptomatic therapy. Following severe sepsis, septic shock
or other shocks, combined with multiple organ failure, the ANR is an autonomous prognosis
worsening factor.
Should the results of our study show a correlation between the production of HSP and the
outcome of children with ANR, further studies would be required, to examine the
pathophysiological relevance of HSP in ANR. We would then be able to determine a high risk
population for ANR. A modulation of ANR therapy might be a result of further studies.
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Observational Model: Case Control, Time Perspective: Prospective
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