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The Effect of Sirolimus on the Pharmacokinetics of Tacrolimus

Kidney Transplantation Clinical Trial

Official title:
The Effect of Sirolimus on the Pharmacokinetics of Tacrolimus

Clinical Trial Summary

The purpose of this study is to understand whether the pharmacokinetics of tacrolimus is influenced by the concurrent use of sirolimus.

Clinical Trial Description

The controlled clinical trial held in NTUH in 2001 revealed that the bioavailability of tacrolimus when combined with sirolimus is lower than that reported in the literature where tacrolimus was not combined with sirolimus. To determine if the difference was due to the drug interaction between sirolimus and tacrolimus, a controlled clinical trial was proposed.

The purpose of this study is to understand whether the pharmacokinetics of tacrolimus is influenced by the concurrent use of sirolimus. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00166829
Study type Interventional
Source National Taiwan University Hospital
Contact Meng-Kun Tsai, MD, PhD
Phone 886-2-23123456
Email mark9@ha.mc.ntu.edu.tw
Status Recruiting
Phase Phase 4
Start date May 2004
View Details
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