Recurrent Small Lymphocytic Lymphoma Clinical Trial
Official title:
A Phase II Trial of Thalidomide (NSC #66847, IND #48832) for Patients With Relapsed or Refractory Low Grade Non-Hodgkin's Lymphoma
Phase II trial to study the effectiveness of thalidomide in treating patients who have relapsed or refractory low-grade non-Hodgkin's lymphoma. Thalidomide may stop the growth of non-Hodgkin's lymphoma by stopping blood flow to the tumor
PRIMARY OBJECTIVES:
I. To estimate the response rate and time-to-progression (TTP) in previously treated
patients with low grade non-Hodgkin's lymphoma treated with thalidomide.
II. To evaluate the effect of thalidomide on microvascular density in the bone marrow of
patients with low grade cell non-Hodgkin's lymphoma.
III. To evaluate the effects of thalidomide on bFGF levels in serum and urine.
OUTLINE:
Patients receive oral thalidomide once daily. Treatment continues in the absence of disease
progression or unacceptable toxicity.
Patients are followed every 6 months for 2 years and then annually for 3 years.
PROJECTED ACCRUAL: A total of 21-45 patients will be accrued for this study.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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