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NCT ID: NCT03773640 Completed - Clinical trials for Temporomandibular Joint Dysfunction Syndrome

The Application of Radio Frequency Waves

Start date: April 1, 2018
Phase: N/A
Study type: Interventional

The aim of the study was to evaluate the influence of radio waves on the functioning of masseter muscles in the course of painful functional disorders of the organ, and thus the usefulness of these procedures in the treatment supporting temporomandibular joint dysfunction. Material and method The study group I (20 patients) and control group II (20 patients) consisted of patients, aged 19 to 45 years, of both sexes, who reported to the Consulting Room of Temporomandibular Joint Dysfunction in Institute of Dentistry in Krakow to undertake prosthetic treatment of pain form of temporomandibular disorders with the dominant muscle component. Study group (I) consist of patients who were treated with the occlusal splints and radio frequency currents. In the case of application of radiation to the muscle area, the energy was 20 J and 15 J to the area of the masticatory muscles, the frequency was 3 MHz, bipolar technique, the duration of the procedure was 10 minutes, the coupling substance was a gel for ultrasound examinations. The control group ( II) consisted of 20 patients treated with occlusion splints and sonophoresis procedures. For the area of mastication muscles 0.9 W/cm² treatments were applied, the duty factor was 80%, the treatment time was 10 minutes, and the medical substance was 25%Voltaren gel.

NCT ID: NCT03773276 Completed - Clinical trials for Living Donor Liver Transplantation

Norepinephrine Boluses in Liver Transplantation

Start date: December 17, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

We study the efficacy of Norepinephrine boluses on prevention of postreperfusion syndrome during living donor liver transplantation. NE and Post-reperfusion: On portal vein declamping, we will start rapid 500 ml 4% albumin infusion or packed RBCs (according to the anhepatic hemoglobin level 5 min before declamping) through 14 Gauge peripheral venous cannula in all patients. NE boluses technique; We will inject NE boluses in the C.V.P port of the pulmonary artery catheter with 5 ml saline flushing after each. After reperfusion, we will start bolus noradrenaline 20 µg if mean arterial blood pressure (mABP) decreases by 10 % or more of the basal reading (immediately before portal vein declamping after ensuring withholding of the surgical manipulation). Additional NE boluses will be given as follow; - If mABP rises to 65 mmHg (lowest target level), we will hold NE boluses. - If mABP remains constant or begins to rise but did not reach 65 mmHg, we will give 20 µg after 10 seconds from the previous bolus - If mABP continues to drop, we will add 10 µg to the previous dose after 10 seconds and can be repeated. - If mABP remains below 65 mmHg more than 1 minute, we will give the scheduled bolus NE with adding 10 µg adrenaline boluses.

NCT ID: NCT03773198 Completed - Clinical trials for Patient Requiring Scheduled Conventional Orthopedic Surgical Intervention of the Upper or Lower Limb

Effectiveness of Energy Resonance by Skin Stimulation in the Management of Anxious Patients Who Require Scheduled Orthopaedic Surgery

ERESCAO
Start date: April 5, 2019
Phase: Phase 3
Study type: Interventional

The need for a surgical procedure may cause a patient to experience reactive anxiety. This reaction is appropriate if it is of low to moderate intensity. On the other hand, various studies have shown that postoperative awakening is more complicated if the patient experiences major preoperative anxiety. Thus, reducing anxiety could be a tool for preventing chronic pain. For several years now, the investigator's facility has been implementing Energy Resonance through Cutaneous Stimulation (ERCS), a method based on "listening" to the body's vibrations through the fingers on points based on the mapping of meridians in Chinese medicine. ERCS practitioners have noted the benefits of this method, particularly in soothing patients. It therefore seems necessary to detect and manage this anxiety beforehand and ERCS seems appropriate in this situation.

NCT ID: NCT03772847 Completed - Clinical trials for Neurological Improving

Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial

GIANT
Start date: July 31, 2018
Phase: Phase 4
Study type: Interventional

Previous clinical studies have confirmed that revascularization or recanalization rate after intravenous thrombolysis is closely related to the formation of thrombus, which also results in poor neurological function after thrombolysis. Platelet activating factor (PAF) strong platelet aggregation may be involved in thrombosis. Formation process. The main components of Ginkgolide injection (Ginkgo) are ginkgolide, ginkgolides A, ginkgolides B and ginkgolides C. Ginkgo biloba lactone can antagonize PAF and has strong anti-platelet aggregation. . Therefore, it can be speculated that ginkgolides injection combined with alteplase intravenous thrombolysis may improve the recanalization rate after thrombolysis and reduce the reocclusion rate. In addition, clinical studies have also found that ginkgolide injection has a good auxiliary effect on hypertensive intracerebral hemorrhage, which can regulate inflammatory factors such as IL-6, TNF-α and high-sensitivity C-reactive protein (CRP) in patients. Recovery of neurological function in patients. It is well known that TNF-α, IL-β, IL-1, IL-6, IFN-γ, etc. are all inflammatory factors associated with reperfusion injury. Therefore, we speculate that ginkgolides injection may also regulate inflammatory factors associated with reperfusion injury, such as IL-6, TNF-α, thereby reducing reperfusion injury, thereby improving patient prognosis. The aim of this study was to determine the clinical efficacy of ginkgolides injection combined with alteplase in the treatment of acute ischemic stroke, and to improve the prognosis of patients with thrombolysis.

NCT ID: NCT03772769 Completed - Clinical trials for Odontogenic Deep Space Neck Infection

Diagnostic Modalities for Severe Odontogenic Infections Using Rapid, Target Enriched Multiplex PCR (TEM- PCR) by Diatherix

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the sensitivity and specificity of the Target Enriched Multiplex (TEM) polymerase chain reaction (PCR) platform for the rapid molecular diagnosis and treatment of odontogenic deep space neck infections.

NCT ID: NCT03772756 Completed - Clinical trials for Pancreatic Adenocarcinoma Non-resectable

EUS-RFA for Unresectable Pancreatic Ductal Adenocarcinoma

Start date: December 20, 2018
Phase: N/A
Study type: Interventional

the study evaluate the efficacy and safety of EUS-RFA using Habib EUS-RFA catheter with a prospective randomised trial in patients with inoperable PDAC.

NCT ID: NCT03772730 Completed - Clinical trials for Pelvic, Acetabular, Femur, or Diaphyseal Tibial Operative Orthopaedic Injuries

Patient-Specific Precision Injury Signatures in Multiply Injured Orthopaedic Patients

PRECISE
Start date: March 20, 2019
Phase:
Study type: Observational

The purpose of this study is to evaluate the use of precision methods that quantify injury and response to injury to predict how short-term clinical outcomes are affected by initial and staged orthopaedic interventions in multiply injured patients (MIPs) who sustain major orthopaedic trauma.

NCT ID: NCT03772704 Completed - Clinical trials for Mechanical Complication of Cardiac Electronic Device

Multicenter Imaging in Lead Extraction Study

MILES
Start date: December 13, 2018
Phase:
Study type: Observational [Patient Registry]

The primary objectives of this registry is to correlate the amount of fibrosis as documented on Electrocardiogram (ECG) gated Computed Tomography (CT) scans with ease of advancing sheaths over the leads through the SVC zone during lead extraction.

NCT ID: NCT03772678 Completed - Clinical trials for None - Study is to Determine Safety in Healthy Participants

A Phase I Study to Evaluate LSALT Peptide

Start date: June 27, 2019
Phase: Early Phase 1
Study type: Interventional

A phase I double-blind, placebo-controlled, randomized, single and multiple ascending dose finding study to evaluate the safety and pharmacokinetic profile of LSALT peptide in healthy participants

NCT ID: NCT03772210 Completed - Clinical trials for Transcranial Direct Current Stimulation

Mechanism and Dosimetry Exploration in TES Magnetic Resonance Current Mapping Methods

TES
Start date: January 3, 2019
Phase: N/A
Study type: Interventional

In this study the investigators will explore dosimetry in transcranial electrical stimulation using a novel magnetic resonance imaging technique that can determine how electrical stimulation distributes within the brain. The investigators will then combine this imaging technique with functional MR imaging to attempt mechanistic associations. If successful, the study outcomes will be an improved understanding of the interactions between electric current distributions and structures presumed to be targeted by stimulation.