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NCT ID: NCT02281032 Enrolling by invitation - Clinical trials for Nursing Home Residents With Palliative Care Needs

Informed Palliative Care in Nursing Homes Through the interRAI Palliative Care Instrument

interRAI PC
Start date: November 2013
Phase: N/A
Study type: Interventional

BACKGROUND Nursing homes are important locations for palliative care. Through comprehensive geriatric assessments (CGAs), evaluations can be made of the palliative care needs of nursing home residents. The interRAI Palliative Care instrument (interRAI PC) is a CGA that evaluates diverse palliative care needs of adults in all healthcare settings. The evaluation results in Client Assessment Protocols (CAPs: indications of problems that need addressing) and Scales (e.g. Palliative Index for Mortality (PIM)) which can be used to design, evaluate and adjust care plans. This study aims to examine the effect of using the interRAI PC on the quality of palliative care in nursing homes. Additionally, it aims to evaluate the feasibility and validity of the interRAI PC. METHODS This study covers phases 0, I and II of the Medical Research Council (MRC) framework for designing and evaluating complex interventions, with a longitudinal, quasi-experimental pretest-posttest design and with mixed methods of evaluation. In phase 0, a systematic literature search is conducted. In phase I, the interRAI PC instrument is adapted for use in Belgium and implemented on the BelRAI-website and a practical training is developed. In phase II, the intervention is tested in fifteen nursing homes. Participating nursing homes fill out the interRAI PC during one year for all residents receiving palliative care. Using a pretest-posttest design with quasi-random assignment to the intervention or control group, the effect of the interRAI PC on the quality of palliative care is evaluated with the Palliative care Outcome Scale (POS). Psychometric analysis is conducted to evaluate the predictive validity of the PIM and the convergent validity of the CAP 'Mood' of the interRAI PC. Qualitative data regarding the usability and face validity of the instrument are collected. DISCUSSION This is the first study to evaluate the validity and effect of the interRAI PC in nursing homes, following a methodology based on the MRC framework. This approach improves the study design and implementation and will contribute to a higher generalizability of results. The final result will be a psychometrically evaluated CGA for nursing home residents receiving palliative care.

NCT ID: NCT02270723 Enrolling by invitation - Clinical trials for Hemorrhage; Complicating Delivery, Coagulation Defect

The Effect of Human Albumin on Coagulation Competence and Hemorrhage

Start date: August 2014
Phase: Phase 4
Study type: Interventional

In a randomized clinical trial, the purpose is to investigate if perioperative coagulation and hemorrhage is influenced by colloid or crystalloid.

NCT ID: NCT02270216 Enrolling by invitation - Clinical trials for Cardiovascular Responses in Elderly With Isolated Systolic Hypertension

Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension

Start date: May 2014
Phase: N/A
Study type: Interventional

Aim to study the exercise responses to both static and dynamic exercise in elderly people with and without essential isolated systolic hypertension, seeking to identify potentially dangerously high responses

NCT ID: NCT02253485 Enrolling by invitation - Clinical trials for Immune Globulin, Prophylaxis, Telbuvidine, Vaccine

Efficacy of Antiviral Therapy in Pregnancy in Preventing Vertical Transmission of HBV in Mothers With a High Viral Load

Start date: August 2012
Phase: N/A
Study type: Observational

Mother-to-child transmission (MTCT) is the most common route of hepatitis B virus (HBV) infection. After given standard immunoprophylaxis, MTCT still occurred in some infants born to a HBsAg positive mothers with high HBV DNA load. The main purpose of this study is evaluating the efficacy of methods used in blocking MTCT of HBV in infants born to a HBsAg positive mothers with high serum HBV DNA loads.

NCT ID: NCT02244515 Enrolling by invitation - Clinical trials for Emergence Deliruim; Cerebral Palsy

Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy

Start date: June 2014
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether dexmedetomidine is effective in the treatment of emergence deliruim after sevoflurane anesthesia in children with cerebral palsy.

NCT ID: NCT02228330 Enrolling by invitation - Clinical trials for Malignant Neoplasm of Urinary Bladder

Prospective Clinical Trial - Obturator Reflex Predictors and Blockage

Start date: July 2014
Phase: N/A
Study type: Interventional

The aim of this study is to estimate the incidence rate of obturator nerve reflex and leg jerking during Transurethral Resections of Bladder Tumors (TURBTs), evaluate the efficacy of obturator nerve block in the prevention of inadvertent muscle spasm, and to identify predictors for both the jerking reflex and successful nerve block.

NCT ID: NCT02220530 Enrolling by invitation - Clinical trials for Ambulatory Patients Referred for a First-time Colonoscopy

Sedation Effect on the Global Quality Colonoscopy

Start date: October 2014
Phase: N/A
Study type: Observational [Patient Registry]

This study aims to assess the impact of the use of sedation on the overall quality of the colonoscopy, therefore addressing each and every one of its dimensions, namely: scientific and technical quality, perceived quality and safety.

NCT ID: NCT02204215 Enrolling by invitation - Sepsis Clinical Trials

Electric Acupuncture for ICU-acquired Weakness in Mechanical Ventilation Patients

EA-ICUAW
Start date: January 2014
Phase: N/A
Study type: Interventional

Intensive care unit acquired weakness (ICU-AW) is common and dramatically affect recovery. The purpose of this study is to determine whether electric acupuncture therapy is effective in the treatment of ICU-AW especially in the patients receiving mechanical ventilation with sepsis or multiorgan system failure.

NCT ID: NCT02193607 Enrolling by invitation - Clinical trials for Pelvic Organ Prolapse

Outcomes of Pelvic Surgery With and Without Anti-incontinence Procedure in Occult Stress Urinary Incontinence Patients

PTOS
Start date: January 2014
Phase: N/A
Study type: Interventional

1. To evaluate whether a standardized tension-free vaginal tape-obturator(TVT-O) procedure, when added to a planned improved reconstruction pelvic surgery, improves the rate of urinary stress continence in subjects with occult stress incontinence. 2. Observe the immediate and short-term complications, overall urinary tract function, and other aspects of pelvic health between subjects with and without a TVT-O procedure.

NCT ID: NCT02184598 Enrolling by invitation - Clinical trials for Attention-deficit/Hyperactivity Disorder.

Randomized Controlled Trial With Use of Cognitive Training in Children and Adolescents With ADHD

Start date: July 2014
Phase: N/A
Study type: Interventional

Purpose: This project assess the effectiveness of a cognitive training as an add-on intervention to drug treatment in children and adolescents diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) compared to a placebo training. The cognitive training consists of 6 computerized games that are based on principles of neuroplastic change. ADHD: current treatment - International clinical guidelines indicate that pharmacological interventions in particular stimulants are the first-line treatment for ADHD. However, about 30% of children affected by the disorder do not respond to medication alone, exhibit partial response or can not tolerate the adverse effects. In addition there is a group of parents who do not accept the use of medication for the treatment of ADHD in their children. In recent years cognitive training has received considerable attention as a treatment to ADHD. The evidence base for cognitive training programs are still forming with few randomized placebo-controlled studies. However, this approach seems to be effective either as a treatment for ADHD - and others cognitive disorders in childhood - or as a tool to enhance cognitive ability and school performance in children and adults. No previous study has evaluated this cognitive intervention in a clinical trial with placebo-controlled intervention and as an adjunctive treatment to medication. Additionally, the investigators will assess brain changes associated with this intervention using neuroimaging (fMRI).