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Filter by:This study is a single-center, single-arm, prospective phase II clinical study, which mainly evaluates the efficacy and safety of pyrotinib maleate combined with oral vinorelbine in the treatment of HER2-positive advanced breast cancer.
A Randomized, double-blind, placebo-controlled, multi-center Phase 3 study evaluating efficacy, safety and pharmacokinetics of Trilaciclib In Extensive-Stage Small Cell Lung Cancer Patients Receiving Carboplatin combined with Etoposide or Topotecan The study consists of 2 parts: Part 1: safety run-in and pharmacokinetics evaluation of 12 ES-SCLC patients (6 each for first line and second/third line ES-SCLC patients); Part 2: randomized, double-blind, placebo-controlled efficacy confirmation study of 80 ES-SCLC patients (stratified by first line and second/third line ES-SCLC, ECOG PS [0-1 vs 2] and brain metastases. The study includes screening period, treatment period, safety follow-up and survival follow-up.
The purpose of this randomized controlled trial is to evaluate the impact of patient and provider facing educational materials and peer comparison on medical testing conversations during annual physicals. The investigators hypothesize that education materials and peer comparison will improve conversation quality about medical testing decisions.
Various stretches are used to lengthen the posterior shoulder capsule. No study has reported the comparison of the pragmatic posterior capsular stretch and cross body stertch
Congenital diaphragmatic hernia (CDH) is a life-threatening condition with long-term complications including respiratory tract infections, respiratory muscle weakness, and abnormal lung functions. This study, therefore, has been designed to ascertain the effect of chest resistance exercise and chest expansion exercise on respiratory muscle strength, lung function, and chest mobility in children with post-operative CDH.
Irritable bowel syndrome (IBS) is the most common functional bowel disorder, being present in approximately 10% of adult Europoid population. The etiology of IBS is elusive. Literature indicates that modification of patients´colonic microbiota might ameliorate the condition. Here we test an intervention by faecal microbiota transplantation of artificially inflated microbiome diversity, versus autoclaved placebo.
This is a Phase 1b multi-center, randomized, double-blind, dose-ranging, placebo-controlled, adaptive study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD) of TERN-201 in patients with non-cirrhotic NASH.
The purpose of this study is to evaluate the effects of videogame-like digital therapy on attentional functioning and symptoms in adolescents ages 13-17 diagnosed with ADHD
COVID-19 is respiratory disease caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), a novel coronavirus which has spread rapidly across the world with over 149.9 million laboratory confirmed cases and over 3.1 million reported deaths since December 2019. Approximately 4-8% of hospitalized patients with COVID-19 have co-infection with bacterial pathogens however there is widespread and often broad-spectrum antibiotic use in these patients. This is a prospective, multi-center, non-inferiority pragmatic clinical trial of antimicrobial stewardship prospective audit and feedback versus no antimicrobial stewardship intervention on physicians attending to patients with proven SARS-CoV-2 infection confirmed by nucleic acid testing in the preceding 2 weeks of hospitalization for acute COVID-19 pneumonia. Prospective audit and feedback is the real time review of antibacterial prescriptions and immediate feedback to prescribers to optimize antimicrobial prescriptions. Hospital beds will be stratified by COVID unit and critical care unit beds, and will be computer randomized in a 1:1 fashion into 2 arms (antimicrobial stewardship intervention versus no antimicrobial stewardship intervention) prior to study commencement at the participating site. Patients hospitalized to study-eligible beds will be followed for primary and secondary outcomes. The objective of this study is to determine the effect of an antimicrobial stewardship intervention (prospective audit and feedback) on clinical outcomes in patients hospitalized with acute COVID-19.
Glenohumeral internal rotation deficit (GIRD) is common physical deficiency found both teenager and overhead many sports for example baseball, cricket, and tennis. GIRD is generally categorized as simultaneous deficits of internal rotation (IR) and total arc of motion in the dominant side. GIRD causes increase muscle stiffness, capsular changes ( hyperplasia) , muscle imbalance leads to humeral retroversion. The objective of the study will be to Compare the effects of Mulligan internal rotation Mobilization and post isometric relaxation technique on Pain, Range of motion and function in athletes with Glenohumeral Internal Rotation Deficit This study will be a Randomise Control trial and will be conducted Pakistan cricket board acedmy and in outpatient department of physical therapy, AL REHMAN Hospital Lahore . The study will be completed within the time duration of six months . Convenient sampling technique will be used to collect the data. A sample size of 14 patients will be taken in this study Comparison of Mulligan internal rotation Mobilization and post isometric relaxation technique on Pain and function in athletes with Glenohumeral Internal Rotation Deficit. Patients will be divided into two groups. (Group A will be treated with mulligan MWM AND Sleeper stretch whereas Group B will be treated with post isometic relaxtion technique and sleeper stretch ). SPADI score will be used to ask some questions related to patients symptoms and daily activities and Numeric pain rating scale will be used to measure pain intensity. UNIVERSAL GONIOMETER will be used to measure ROM of shoulder joint All participants of the study will fill the SPADI score and Numeric pain rating scale on day 1 as pre treatment values and at the end of week 2 as post treatment values respectively . The collected data will be analyzed on SPSS 25.