Osteoporosis Clinical Trial
Official title:
The Optimal Long Term Treatment Strategy of Anti-resorptive Medications---The Extension of Denosumab Sequential Therapy
This study is to investigate whether the alternating use of Prolia (Denosumab) and Aclasta (Zoledronic acid) can continue to increase bone density.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | December 31, 2030 |
Est. primary completion date | December 31, 2026 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 50 Years to 80 Years |
Eligibility | Inclusion Criteria: 1. Postmenopausal women or men over 50 years old 2. Denosumab treatment for at least two years and less than three years (up to five doses). Exclusion Criteria: 1. . Estimated glomerular filtration rate <35 ml/min. 2. Malignancy 3. Continuous steroid treatment, hormone therapy or other medical treatment affecting bone metabolism 4. Secondary osteoporosis 5. Metabolic bone diseases 6. Contraindications to ZOL 7. Patients older than 80 years old 8. Hypocalcemia |
Country | Name | City | State |
---|---|---|---|
Taiwan | National Taiwan University Hospital, Yunlin branch | Douliu | Yunlin County |
Lead Sponsor | Collaborator |
---|---|
National Taiwan University Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Bone mineral density of femoral neck Bone mineral density of femoral neck | Bone mineral density of femoral neck | 7 years | |
Secondary | Bone mineral density of lumbar spine | Bone mineral density of lumbar spine | 7 years | |
Secondary | Bone mineral density of total hip | Bone mineral density of total hip | 7 years |
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