Osteoporosis Clinical Trial
Official title:
Evaluation of Clinical and Bone Density Improvement After Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord on Osteoporosis Patients (Clinical Trial)
This study will assess the effectiveness of the allogeneic mesenchymal cell from umbilical cord in improving the quality and quantity of spinal density of osteoporosis patients proven by the results of Bone Mass Density (BMD) examination compared to baseline and evaluate improvement of quality of pain with visual analog scale (VAS).
Currently, preventive and therapeutic strategies for osteoporosis patients are based on
calcium and vitamin D supplementation, the use of pharmacological agents that inhibit bone
resorption such as bisphosphonates, and sometimes calcitonin. Although bisphosphonates have
been found to reduce osteoporosis, clinical use for these drugs has been limited because of
its potential to produce serious side effects, such as mandibular osteonecrosis and atypical
femoral fractures. Therefore, new therapeutic strategies for osteoporosis are needed.
This study will assess the effectiveness of the allogeneic mesenchymal cell from umbilical
cord. Patients who have received mesenchymal stem cell therapy (MSC) are expected to have
positive effects such as reduced pain sensation in the back assessed by Visual Analog Scale
(VAS), improvement in the range of motion (ROM), improving the quality of osteoporosis
patients's bone proven by the results of Bone Mass Density (BMD) and improvement in patients'
quality of life.
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