Osteoporosis Clinical Trial
Official title:
Prevalence of Osteoporosis and Fractures in Patients With Hepatic Cirrhosis and Investigation of the Associated Factors
Osteoporosis is a common complication in chronic liver disease, especially in the late
stages of the disease. Good nutrition and calcium and vitamin D supplementation are
recommended for the prevention and treatment of osteoporosis. There are no specific
guidelines for its pharmacological treatment, but bisphosphonates have been shown to be
effective in increasing bone mass in patients with chronic cholestasis, with a good safety
profile.
There are few studies evaluating the prevalence of osteoporosis in patients with cirrhosis
(except for primary biliary cholangitis (PBC)). There are no clear recommendations for
osteoporosis screening in cirrhotic patients. A diagnosis and early therapeutic intervention
before the onset of the complications derived would significantly improve the quality of
life and decrease the morbidity and mortality associated with osteoporosis and fractures
Objective:
-To assess the prevalence of osteoporosis and fragility fractures in patients with liver
cirrhosis in our country and the risk factors associated
Method:
Patients diagnosed with hepatic cirrhosis, other than PBC, will be included in any Child
stage during a hospital admission. Epidemiological, demographic, clinical, analytical and
imaging data (dorso-lumbar spine radiography, bone densitometry and Trabecular Bone Score)
will be evaluated. A descriptive statistic of the main variables will be carried out as well
as a multivariate analysis to evaluate the predictive factors of osteoporosis and / or
fragility fractures
Osteoporosis is a common complication in chronic liver disease, especially in the late
stages of the disease. The main mechanism involved in the development of osteoporosis in
patients with cirrhosis is the deficit of bone formation due to the harmful effect of
substances such as bilirubin and bile acids or the toxic effect of alcohol or iron on
osteoblasts .
Good nutrition and calcium and vitamin D supplementation are recommended for the prevention
and treatment of osteoporosis. There are no specific guidelines for its pharmacological
treatment, but bisphosphonates have been shown to be effective in increasing bone mass in
patients with chronic cholestasis, with a good safety profile.
Hospital admissions in relation to osteoporotic fractures in cirrhotic patients are frequent
with a high morbidity and mortality rate. There are few studies evaluating the prevalence of
osteoporosis in patients with cirrhosis with a different etiology from PBC and the existing
series are published years ago with few patient numbers. There are no clear recommendations
for osteoporosis screening in cirrhotic patients. A diagnosis and early therapeutic
intervention before the onset of the complications derived would significantly improve the
quality of life and decrease the morbidity and mortality associated with osteoporosis and
fractures
Objective:
- To assess the prevalence of osteoporosis and fragility fractures in patients with liver
cirrhosis in our country.
- To assess the risk factors associated with osteoporosis and fractures in these
patients.
Method:
Patients diagnosed with hepatic cirrhosis, other than PBC, will be included in any Child
stage during a hospital admission. Epidemiological, demographic, clinical, analytical and
imaging data (dorso-lumbar spine radiography, bone densitometry and Trabecular Bone Score)
will be evaluated. Additional visits to those already carried out in normal practice will
not be necessary. A descriptive statistic of the main variables will be carried out as well
as a multivariate analysis to evaluate the predictive factors of osteoporosis and / or
fragility fractures
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