Osteoporosis Clinical Trial
Official title:
Thiazolidinedione-Induced Bone Loss: Effects on Bone Marrow Stromal Cell Differentiation Capacity and Osteoblast Formation
Thiazolidinediones (TZDs) are a commonly used antidiabetic drugs currently used by over a million patients in the United States. Recent studies have shown that treatment with TZD may increase the risk of bone fractures. The cause of bone loss is not known. We believe that TZD may cause increased accumulation of fat in the bone marrow, which may cause decrease bone formation and weak bones. .
This study aims to determine if TZDs increase the amount of fat and decrease the number of
bone producing cells in the bone marrow.
A total of 5 subjects who require surgery for mandible (jaw) fracture and bone graft will be
recruited. Some patients who will undergo mandible surgery will require a bone graft. In
this procedure, a small piece of bone from the hip is placed in the mandible. In this study,
a small amount of bone marrow fluid (5 mL or 1 teaspoon) will be obtained after the bone
graft is completed. Obtaining the bone marrow will not result in additional pain or health
problems. The effect of TZD on bone marrow and bone forming cells will be studied. The cells
obtained during surgery will be grown at Dr Beck's laboratory at Emory University School of
Medicine.
A working hypothesis suggests that the increased fracture risk in patients taking TZDs is
the result of TZDs altering the differentiation capacity of bone marrow stromal cells
pushing them towards the adipocyte lineage at the cost of osteoblast formation thereby
decreasing bone formation.
Study AIM:To determine whether TZD exposure in vitro alters bone formation and the
differentiation capacity of bone marrow stromal cells by promoting adipocyte lineage
differentiation and lowering osteoblast formation.
;
Observational Model: Case-Only, Time Perspective: Prospective
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