Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise

Osteoporosis Clinical Trial

Official title:

Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00572871
• Other study ID #: 1097239
• Secondary ID: 65438
• Status: Completed
• Phase: N/A
• First received: December 12, 2007
• Last updated: September 30, 2016
• Start date: December 2007
• Est. completion date: December 2009

Study information

• Verified date: September 2016
• Source: University of Missouri-Columbia
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of weight lifting (resistance exercise) or jumping (plyometrics). We are also interested in determining if the bone marker response to exercise is altered by changing the negative energy state caused by the exercise treatment, when subjects are given a moderate calorie meal.

Description:

Bone tissue responds to impact and strain forces, like high-intensity exercise, by upregulating the bone remolding process, resulting in the deposition of calcium phosphate minerals into the collagen matrix of bone. Bone remodeling is a continually active process that involves both activation cells regulating bone formation (osteoblasts) and resorption (osteoclasts). Alterations in the balance between formation and resorption are critical for changes in bone density and mineral content to occur, which is regulated by several hormones including vitamin D and growth hormone, the sex hormones estrogen and testosterone, and parathyroid hormone. Importantly, it remains unclear how single bouts of physical activity contribute to the overall changes in remodeling and whether those acute alterations can be detected in the hours after exercise. Additionally, research studies examining the effects of exercise on bone remodeling often draw blood samples after 24 hours of physical inactivity, potentially diminishing the magnitude of the exercise response. Therefore, we plan to evaluate the acute effects of plyometrics and resistance exercise on changes in serum hormones and markers of bone turnover in non-sedentary, healthy males, with or without a moderate calorie supplement.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: December 2009
• Est. primary completion date: December 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 25 Years to 65 Years

Eligibility

Inclusion Criteria:

• Male

• No symptoms of disease

• Non-sedentary

• Age 25-65

Exclusion Criteria:

• Medications or supplements that affect bone metabolism or prevent exercise

• Previous or current medical condition affecting bone health, including osteoporosis.

• Cardiovascular disease

• Metallic implants affecting accuracy of bone density scan

• Current smoker

• Current participation in high-intensity jumping or resistance exercise in the last 3 months.

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Bone Diseases, Metabolic
• Osteopenia
• Osteoporosis

Intervention

Other:
• plyometric exercise
single bout of plyometric exercise
• resistance exercise
single bout of resistance exercise
• No exercise
Will not do any exercise

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Missouri-Columbia

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	serum bone turnover markers		24 hours	No
Secondary	serum hormones regulating bone turnover		24 hours	No