Osteoporosis Clinical Trial
Official title:
The Change of Bone Markers After Low Dose Alendronate in Postmenopausal Women
High bone turnover with the bone resorption exceeding bone formation is a major mechanism of
postmenopausal osteoporosis. Therefore, inhibition of bone resorption is a rational approach
for the prevention. The Objective of the current study was to determine the short-term
efficacy of once-weekly low dose alendronate in the prevention of bone loss in early
postmenopausal Korean women with moderate bone loss via bone turnover markers.
This study was a 12-week, randomized, double-blind clinical trial compared the effects of
placebo with alendronate 20 mg once weekly. All subjects received supplemental calcium 600
mg and vitamin D 400 IU daily. Fifty two postmenopausal women (the ages between 50-65 year)
with lumbar spine BMD at least 2.0 SD below the peak young adult mean were recruited at
Eulji University Hospital, Daejeon, Korea. BMD was measured by DXA at baseline and serum
alkaline phosphatase, osteocalcin and C-terminal telopeptide of type I collagen was measured
at baseline and 12 weeks after treatment.
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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