Osteoporosis Clinical Trial
Official title:
An Open-Label, Partially Randomized, Interaction Study to Evaluate the Effects of SB-751689 on the Pharmacokinetics of Rosuvastatin and Atorvastatin or the Effects of Ketoconazole on the Pharmacokinetics of SB-751689 in Healthy Postmenopausal Female Subjects
The first purpose of this study is to determine if taking SB-751689 along with Rosuvastatin
(CRESTOR) or Atorvastatin (LIPITOR) will change how Rosuvastatin or Atorvastatin are
absorbed and eliminated from the body. Rosuvastatin and Atorvastatin are prescription
medications used to treat patients with high cholesterol. Patients who would take SB-751689
for osteoporosis might also take Rosuvastatin or Atorvastatin for high cholesterol. In an
earlier study, SB-751689 was shown to lower the blood levels of Rosuvastatin when the two
drugs were taken at the same time. Lower blood levels of Rosuvastatin could mean that it
would not be as effective in lowering cholesterol. In this study SB-751689 will be taken
alone, Rosuvastatin will be taken alone, SB-751689 and Rosuvastatin will be taken together,
and SB-751689 will be taken 12 hours before Rosuvastatin is taken. This study will help
determine if the two drugs should be taken 12 hour apart to prevent lower Rosuvastatin blood
levels. Atorvastatin will be taken alone and at the same time as SB-751689 to determine if
Atorvastatin blood levels are lower when taken at the same time as SB-751689.
A second purpose of this study is to determine if taking another drug called Ketoconazole
(Nizoral) along with SB-751689 will change how SB-751689 is absorbed and eliminated from the
body. Ketoconazole is a prescription medication used to treat patients with fungal and yeast
infections.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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