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µMRI of Therapeutic Intervention in Postmenopausal Osteoporosis — TERIZOL  

Osteoporosis, Osteopenia Clinical Trial

Official title:
NMR Imaging and Stereological Analysis of Trabecular Bone in Female Subjects 60 and Older at Risk of Fracture Receiving Either Zoledronic Acid or Teriparatide

Clinical Trial Summary

The purpose of this study is to apply a novel advanced magnetic resonance imaging methodology to evaluate the response to drug intervention involving two treatment arms of postmenopausal participants with osteoporosis, randomized into either a teriparatide (Forteo™) or zoledronic acid (Reclast™) group.

Clinical Trial Description

The overall design is to determine and compare the effect of teriparatide and of zoledronic acid on trabecular architecture by magnetic resonance imaging of the midshaft tibia. Post-menopausal women, aged 60 or older with osteoporosis and/or at increased risk of fracture, will be randomized to receive either teriparatide or zoledronic acid. Trabecular microarchitecture, biomechanical parameters and bone mineral density will be examined at 0 and 12 months at 3T MRI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01153425
Study type Interventional
Source University of Pennsylvania
Contact
Status Completed
Phase Phase 4
Start date July 2008
Completion date December 2012
View Details
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