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Hematopoietic Stem Cell Transplantation for Malignant Infantile Osteopetrosis

Osteopetrosis Clinical Trial

Official title:
Hematopoietic Stem Cell Transplantation for Malignant Infantile Osteopetrosis

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy and side effects of donor hematopoietic cells using chemotherapy regimen without total-body irradiation in children undergoing a hematopoietic stem cell transplant for Malignant infantile osteopetrosis. The blood stem cells will be derived from either related donor or unrelated umbilical cord blood or haploidentical donor.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01087398
Study type Interventional
Source Tehran University of Medical Sciences
Contact Amir Ali Hamidieh, MD
Phone 84902645
Email aahamidieh@sina.tums.ac.ir
Status Recruiting
Phase Phase 2/Phase 3
Start date September 2009
Completion date December 2012
View Details
See also
  Status Clinical Trial Phase
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Completed NCT00004402 - Phase III Randomized Study of Interferon Gamma in Children With Severe, Congenital Osteopetrosis Phase 3
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Terminated NCT00145587 - Stem Cell Transplantation for Children Affected With Osteopetrosis N/A
Completed NCT01199094 - Clinical Assessment of Patients With High Bone Mass Due to Mutation in Lrp5 N/A
Completed NCT00043329 - Post Marketing Surveillance Study of Actimmune in Patients With Severe, Malignant Osteopetrosis Phase 4
Recruiting NCT03333200 - Longitudinal Study of Neurodegenerative Disorders
Completed NCT02666768 - ACTIMMUNE in Intermediate Osteopetrosis Phase 2
Terminated NCT00145886 - rhPTH Therapy for Low Turnover Bone Fragility Phase 1
Terminated NCT00968864 - T-cell Depleted Alternative Donor Transplantation Phase 2
Completed NCT00730314 - Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Phase 1/Phase 2
Active, not recruiting NCT03301168 - Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant Phase 1/Phase 2
Terminated NCT02065869 - Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant Phase 1/Phase 2
No longer available NCT01200017 - Expanded Access Protocol (EAP) Using the CliniMACS® Device for Pediatric Haplocompatible Donor Stem Cell Transplant