Osteopenia Clinical Trial
Official title:
Metabolic Workup in Patients Suffering From Kidney Stone Disease and Show Osteopenic Bone Changes on Non-contrast CT Scan
Patients suffering from acute renal colic are evaluated by non contrast computerized tomography with excellent identification rates of urinary stones. The scan also covers the bones of the ribs, spine and pelvis, allowing measurements of the bone density and identifying early osteopenic changes. Bone demineralization is associated with metabolic changes such as hypercalcemia or hypercalcuria. In this study the investigators will look for correlation between kidney stones, osteopenic bone changes and metabolic abnormalities.
Kidney stones are a common medical condition found in more then 5% of the adult population.
The stones might cause severe pain (due to acute obstruction of a renal unit) , deterioration
of renal function and urinary tract infection. One of the causes of kidney stones is
metabolic changes such as hypercalcemia or hyperoxaluria. Basic evaluation of kidney stones
patients include measurements of calcium, phosphor and uric acid in the serum and is often
negative. Thorough metabolic workup including 24 hours urine collection is not cost effective
and is reserved for patients with frequent recurrence of stone disease.
Metabolic abnormalities are often associated with bone demineralization, of which the
patients are typically unaware. such changes can be detected by the CT scan. On the same
scan, performed for identifying the stone, the radiologist can measure bone density, using
the Hounsfield units, in the L2 vertebral body of and the acetabular area of the pelvis.
In the study, in all patients undergoing CT scan due to renal colic, the bone density will be
measured. Patients with abnormal bone density will undergo a complete metabolic workup
including 24 hours collection of urine and measurements of urinary clearance of calcium,
phosphorous, uric acid, oxalate and citrate . The investigators will look for correlation
between osteopenic changes and metabolic abnormalities.
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