Osteomyelitis Clinical Trial
Official title:
Clinical Results of Chronic Cavitary Long-bone Osteomyelitis Treatment Using S53P4 Bioactive Glass; a Multi-center Study
This clinical trial studies the clinical effectiveness of S53P4 bioactive glass (BAG) as a bacterial growth inhibiting bone graft substitute in a one-stage or two-stage surgical procedure for treatment of chronic long bone osteomyelitis.
In this prospective multicenter study, patients from two different university hospitals in the Netherlands were included. Treatment consisted of debridement surgery, implantation of S53P4-BAG, if necessary wound closure by a plastic surgeon and additional culture based systemic antibiotics. Primary outcome was eradication of infection based on clinical presentation, radiographic imaging and laboratory tests. Secondary analysis was performed on probable risk factors for treatment failure after S53P4-BAG implantation. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04563325 -
Oral-only Antibiotics for Bone and Joint Infections in Children
|
Phase 4 | |
| Not yet recruiting |
NCT06402292 -
Surgical Treatment of Osteoarticular Infections Using Bioactive Bone Substitute
|
N/A | |
| Completed |
NCT03846804 -
Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections
|
N/A | |
| Recruiting |
NCT06084754 -
Effect of Pulsed Electromagnetic Field Stimulation on Localized Pediatric Osteomyelitis
|
N/A | |
| Recruiting |
NCT05177107 -
Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis
|
Phase 2 | |
| Recruiting |
NCT04554108 -
Acute Non-severe Osteomyelitis in Children - Outpatient Management Strategy With Oral Antibiotic Therapy Compared to a Standard Strategy With Conventional Hospitalization and Intravenous Antibiotic Therapy: a Randomized Open-label Non-inferiority Study With Bayesian and Medical-economic Analyses.
|
N/A | |
| Recruiting |
NCT02128256 -
CERAMENT™|G - Bone Healing and Re-infection Prophylaxis
|
Phase 4 | |
| Terminated |
NCT01612962 -
Diagnostic Tests to Help Determine Osteomyelitis
|
N/A | |
| Terminated |
NCT03091439 -
Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Patients With Osteomyelitis
|
Phase 2 | |
| Recruiting |
NCT04936958 -
RETR(Osteomyelitis)
|
||
| Completed |
NCT03802552 -
Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections
|
Phase 1 | |
| Completed |
NCT03559530 -
Acinetobacter Baumannii-related Osteomyelitis: Clinical and Epidemiological Characterization
|
||
| Completed |
NCT00324922 -
Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus Osteomyelitis
|
Phase 3 | |
| Completed |
NCT02084147 -
PET-MRI in Diagnosing Patients With Cancer, Cardiac Diseases, or Neurologic Diseases
|
N/A | |
| Terminated |
NCT02099240 -
Patients Response to Early Switch To Oral:Osteomyelitis Study
|
Early Phase 1 | |
| Withdrawn |
NCT02344511 -
Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis
|
Phase 3 | |
| Completed |
NCT00402064 -
The Influence of Bisphosphonates in the Oral Cavity in Children
|
N/A | |
| Terminated |
NCT02168816 -
Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitis
|
Phase 2 | |
| Completed |
NCT02685033 -
Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Participants With Osteomyelitis
|
Phase 2 | |
| Completed |
NCT02335905 -
Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children
|
Phase 1/Phase 2 |