The Effect of Exercise Training in the Community-dwelling Adults With Chronic Disorders

Osteoarthritis Clinical Trial

Official title: The Effect of Exercise Training in the Community-dwelling Adults With Chronic Disorders

Status Completed

Clinical Trial Summary

Previous studies have demonstrated that resistance training (RT) is beneficial to increase muscle strength, improve functional ability and the ability to rapidly produce force, known as the contractile rate of force development (RFD) in older adults. However, much less research has focused on the effect of RT on the lower extremity muscle strength, contractile RFD and impulse in middle-aged and older people with musculoskeletal conditions, especially for osteoporosis (OP) (or osteopenia) or knee osteoarthritis (KOA). Therefore, the purpose of this study was to investigate the effect of RT on the lower extremity muscle strength, RFD and impulse in middle-aged and older people with musculoskeletal conditions, especially for OP and knee OA (KOA). The investigators hypothesized that such a training program would lead to induce not only specific muscle strength enhancement but also an increment in contractile RFD and impulse.

Clinical Trial Description

Osteoporosis (OP) and osteoarthritis (OA) are the two most common musculoskeletal conditions in older adults, causing high healthcare costs and negative effects on quality of life. Previous studies have reported that OP and OA has a strong association with sarcopenia, a term defined as age-related involuntary loss of skeletal muscle mass and strength or function.A decline of muscle mass and strength in older adults may limit a variety of activities of daily living (ADLs) and increase morbidity and mortality. However, many ADLs often involve faster limb movements with contraction times of 50 - 200 ms (i.e. sit-to-stand performance and avoiding falls). Therefore, in addition to muscle mass and strength, the ability to rapidly produce force, known as the contractile rate of force development (RFD), and the area under the force-time curve, defined as contractile impulse, seem to be important to adequately characterize the performance of ADLs in older adults. Typically, resistance training (RT) is often prescribed to increase muscle strength, improve functional ability and eliminate much of age-associated muscle atrophy and weakness in a healthy population. Other studies have also shown that implementation of RT can help improve RFD in healthy young and elderly individuals following RT. However, it still unclear that the effect of RT on contractile RFD and impulse in middle-aged and older people with musculoskeletal conditions. Therefore, the aim of this study was to examine the effects on the lower extremity muscle strength, contractile rate of force development (RFD), impulse in middle-aged and older people with osteoporosis (OP)(or osteopenia) or knee osteoarthritis (KOA) after 12 weeks of resistance training. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Related Conditions & MeSH terms

• Chronic Disease
• Osteoarthritis
• Osteoporosis

• NCT number: NCT02017067
• Study type: Interventional
• Source: Far Eastern Memorial Hospital
• Status: Completed
• Phase: N/A
• Start date: April 2012
• Completion date: September 2013