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Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee

Osteoarthritis of the Knee Clinical Trial

Official title:
A Double-Blind, Placebo-Controlled, Randomized, Crossover Pilot Study of the Efficacy of Celecoxib 200 mg QD in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee.

Clinical Trial Summary

The purpose of this study is to compare the efficacy of celecoxib versus placebo in delaying the onset of pain and improving walking function in subjects with knee Osteoarthritis

Clinical Trial Description

We have developed a walking model that safely and reproducibly induces pain in subjects with knee OA in a manner that permits the comparison of the effect of different therapies on pain control. In a previous study, we demonstrated that a self-paced 20 minute walk followed by a one-hour rest and a second coordinator-paced 20-minute walk was well tolerated and generated moderate to severe pain in all participants within the time frame of the walk. We will now use this model, but with a crossover design to test the efficacy of celecoxib compared to placebo for the control of knee pain and improvement of walking function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00597415
Study type Interventional
Source University Hospitals Cleveland Medical Center
Contact Michelle Wallette, CMA, CCRC
Phone 216-591-1443
Email michelle.wallette@uhhospitals.org
Status Unknown status
Phase Phase 2
Start date December 2004
Completion date March 2008
View Details
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