Surgery Versus No Surgery for Osteoarthritis (OA) of the Knee

Osteoarthritis of the Knee Clinical Trial

— MRC Knee  

Official title:

Arthroscopic vs. Non-surgical Treatment of Osteoarthritis of the Knee

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00562822
• Other study ID #: mrc123456
• Secondary ID: MCT-15227
• Status: Completed
• Phase: Phase 3
• First received: November 20, 2007
• Last updated: May 21, 2014
• Start date: January 1999
• Est. completion date: August 2007

Study information

• Verified date: May 2014
• Source: University of Western Ontario, Canada
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Health Canada
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to discover whether arthroscopic surgery is helpful in controlling the symptoms of osteoarthritis of the knee.

Description:

Although arthroscopic surgery has been widely used for osteoarthritis of the knee, scientific evidence to support its efficacy is lacking. This study will compare optimized physical and medical therapy alone with arthroscopic treatment in addition to optimized physical and medical therapy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 188
• Est. completion date: August 2007
• Est. primary completion date: August 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Idiopathic or secondary osteoarthritis of the knee with Grade II to IV radiographic severity as defined by the modified Kellgren and Lawrence classification

Exclusion Criteria:

• Patients with inflammatory or post-infectious arthritis

• Those who had undergone previous arthroscopic treatment for knee osteoarthritis

• Those with isolate Grade III to IV medical compartment osteoarthritis with greater than 5 degrees of varus deformity.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Osteoarthritis
• Osteoarthritis of the Knee
• Osteoarthritis, Knee

Intervention

Procedure:
• Arthroscopic surgery
Arthroscopic surgery to treat unresolved symptoms of osteoarthritis of the knee

Other:
• Physical and medical therapy
Treatment with physical and medical therapy alone

Locations

Country	Name	City	State
Canada	London Health Sciences Centre - University Hospital	London	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
University of Western Ontario, Canada	Canadian Institutes of Health Research (CIHR)

Country where clinical trial is conducted

Canada, 

References & Publications (1)

Moseley JB, O'Malley K, Petersen NJ, Menke TJ, Brody BA, Kuykendall DH, Hollingsworth JC, Ashton CM, Wray NP. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2002 Jul 11;347(2):81-8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Function, pain and quality of life based on the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) scores		2 years	No
Secondary	Health utility using the Standard Gamble Technique		24 months	No