Osteoarthritis, Knee Clinical Trial
Official title:
Comparison Efficacy of Oral Fluid Versus Intravenous Fluid Replacement in Postoperative Primary Total Knee Arthroplasty : A Randomized Controlled Trial.
The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty. The main question it aims to answer is: Does oral fluid replacement after primary unilateral total knee arthroplasty provide a patient recover faster than intravenous fluids replacement?
Status | Recruiting |
Enrollment | 130 |
Est. completion date | June 2025 |
Est. primary completion date | December 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years to 85 Years |
Eligibility | Inclusion Criteria: - Age 40-85 years old - ASA I, II - Primary osteoarthritis Exclusion Criteria: - Diuretics use - Morbid obesity - Previous knee surgery - Cannot undergo spinal anesthesia |
Country | Name | City | State |
---|---|---|---|
Thailand | Thammasat University | Khlong Luang | Pathum Thani |
Lead Sponsor | Collaborator |
---|---|
Thammasat University Hospital |
Thailand,
Jennings JM, Mejia M, Williams MA, Johnson RM, Yang CC, Dennis DA. The James A. Rand Young Investigator's Award: Traditional Intravenous Fluid vs. Oral Fluid Administration in Primary Total Knee Arthroplasty: A Randomized Trial. J Arthroplasty. 2020 Jun;35(6S):S3-S9. doi: 10.1016/j.arth.2020.01.029. Epub 2020 Jan 22. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Time to stand and walk | Stand and walk with walker | Postoperative day 1 | |
Secondary | Time up and go | Record time since stand up and walk 3 meters, or 10 feet away, on the floor | 24 and 48 hours | |
Secondary | Incidence of oliguria | Urine output < 0.5ml/kg/hr | Postoperative day 1,2 | |
Secondary | Incidence of nausea/vomiting | record symptom of nausea and vomiting | Postoperative day 1,2 | |
Secondary | Urine specific gravity | Urine specific gravity every 4 hours | Postoperative day 1 | |
Secondary | the levels of certain electrolytes | Blood chemistry | Postoperative day 1,2 | |
Secondary | the levels of creatinine | Blood chemistry | Postoperative day 1,2 | |
Secondary | the levels of blood urea nitrogen (BUN). | Blood chemistry | Postoperative day 1,2 | |
Secondary | Complications | Pulmonary edema, heart failure, acute kidney injury | Until postoperative 3months |
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