Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis

Osteoarthritis, Knee Clinical Trial

Official title:

Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04995250
• Other study ID #: REC/Lhr/1065
• Status: Completed
• Phase: N/A
• Start date: April 1, 2020
• Est. completion date: December 30, 2020

Study information

• Verified date: August 2021
• Source: Riphah International University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Patients with neuropathic pain had longer duration of symptoms increased severity of pain, functional limitation and disability as compare to the patient with general knee osteoarthritis.

Objective: To find out the effects of corrective exercise training for improving neuropathic pain and function in knee OA patients.

Description:

This study was a Quasi experimental study. It was conducted at Horizon Hospital Johar Town Lahore. The study was completed in Six months. Consecutive sampling technique was used to collect the data. The sample size of 16 patients was taken in this study to find out the effects of corrective exercises training for improving neuropathic pain and function in patients with knee osteoarthritis. For descriptive analysis we used frequency, percentages and charts. For quantitative measure. Repeated Measured ANOVA was used.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: December 30, 2020
• Est. primary completion date: November 30, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• ACR Criteria for osteoarthritis

• Neuropathic pain

• Age over 65

• DN4 cut off value is 4/10

• Less than 30 minutes of morning stiffness

• Grade I and II

• Crepitus on active motion

• Bony tenderness

• Bony enlargement

• No palpable warmth of synovium

Exclusion Criteria:

• Knee complain that require urgent medical attention (fracture and infection)

• Diabetes mellitus

• Patients with malignancies

• Neurological disorders

• Systematic musculoskeletal diseases (Parkinson's, rheumatoid arthritis etc)

• Incapability of understanding implication of participants

Related Conditions & MeSH terms

• Neuralgia
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Other:
• corrective exercise training for knee
All patients received 12 weeks (3 days per week) physiotherapy sessions with hot pack, TENS and Ultrasound session for 10 mints and knee isometric, quad strengthening, adductor and abductor strengthening, calf stretch, hamstring stretch, Maitland mobilization, Unconventional Corrective knee exercise protocol treatment: standing on one extremity, up and down on bosu exercise, walking to lateral direction, walking to anterio-posterior direction, walking to anterio-posterior and lateral for 20 mints. Data were collected at baseline, at week 4 and at post treatment (week 12).

Locations

Country	Name	City	State
Pakistan	Riphah Rehabilitation Center	Lahore	Punjab

Sponsors (1)

Lead Sponsor	Collaborator
Riphah International University

Country where clinical trial is conducted

Pakistan, 

References & Publications (6)

Beckwée D, Vaes P, Cnudde M, Swinnen E, Bautmans I. Osteoarthritis of the knee: why does exercise work? A qualitative study of the literature. Ageing Res Rev. 2013 Jan;12(1):226-36. doi: 10.1016/j.arr.2012.09.005. Epub 2012 Sep 28. Review. — View Citation

Knoop J, Steultjens MP, van der Leeden M, van der Esch M, Thorstensson CA, Roorda LD, Lems WF, Dekker J. Proprioception in knee osteoarthritis: a narrative review. Osteoarthritis Cartilage. 2011 Apr;19(4):381-8. doi: 10.1016/j.joca.2011.01.003. Epub 2011 Jan 18. Review. — View Citation

Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM. A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum. 2014 Jun;43(6):701-12. doi: 10.1016/j.semarthrit.2013.11.012. Epub 2013 Dec 4. Review. — View Citation

Polat CS, Dogan A, Sezgin Özcan D, Köseoglu BF, Koçer Akselim S. Is There a Possible Neuropathic Pain Component in Knee Osteoarthritis? Arch Rheumatol. 2017 Apr 24;32(4):333-338. doi: 10.5606/ArchRheumatol.2017.6006. eCollection 2017 Dec. — View Citation

Sazo-Rodríguez S, Méndez-Rebolledo G, Guzmán-Muñoz E, Rubio-Palma P. The effects of progressive neuromuscular training on postural balance and functionality in elderly patients with knee osteoarthritis: a pilot study. J Phys Ther Sci. 2017 Jul;29(7):1229-1235. doi: 10.1589/jpts.29.1229. Epub 2017 Jul 15. — View Citation

Takacs J, Carpenter MG, Garland SJ, Hunt MA. The role of neuromuscular changes in aging and knee osteoarthritis on dynamic postural control. Aging Dis. 2013 Jan 15;4(2):84-99. Print 2013 Apr. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Western Ontario and McMaster Osteoarthritis Index	0-100, 0 means no disability 100 means maximum disability	6 months
Primary	Numeric pain rating scale	0-10,no pain and the worse pain, on an 11 point scale	6 months
Primary	Douleur Neuropathique 4 Questionnaire	The total score is calculated as the sum of 10 items and the cut off value for the diagnosis of neuropathic pain is a total score of 4/10	6 months