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Clinical Trial Summary

To determine whether platelet-rich-plasma (PRP) or HA (hyaluronic acid)injection into synovitis in osteoarthritis(OA) knee can achieve improvement in knee function and reduce synovitis.


Clinical Trial Description

Methods:

sixty patients with OA knee having unilateral or bilateral synovitis validated by ultrasound (N=40) were studied. All the patients were randomized to receive PRP (N=40) or Hyaluronic acid(HA)(N=40) injection twice at 2-week intervals; Clinical assessments were performed using a visual analog scale(VAS) and The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC index) before injection at baseline, 4 weeks(first evaluation) and 12 weeks(secondary evaluation). Imaging evaluation based on color Doppler ultrasound(CDUS) and the depth of synovial fluid accumulation ,and the width of synovial hypertrophy was performed simultaneously. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03167333
Study type Interventional
Source Taipei Veterans General Hospital, Taiwan
Contact Chien-CHIh Wang, MD
Phone 886-958738258
Email candycandywang@gmail.com
Status Recruiting
Phase N/A
Start date March 1, 2020
Completion date March 1, 2020

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