Osteoarthritis, Knee Clinical Trial
Official title:
Minimum Effective Concentration of Bupivacaine for Motor-Sparing Femoral Nerve Block
Femoral nerve blocks are commonly used to provide pain control for total knee replacement,
anterior cruciate ligament (ACL) reconstruction. Commonly employed local anesthetic
concentrations result in motor block of the quadriceps and constitute an inherent risk factor
for patient fall.
The aim of this study is to determine the minimum effective concentration of bupivacaine in
90 % of patients (MEC90) required for a motor-sparing, successful sensory block of the
femoral nerve.
With the approval of Ethics Committee of the University of Chile Clinical Hospital,
approximately 60 patients undergoing ACL repair or TKR will be recruited. All blocks will be
conducted preoperatively in an induction room.Dose assignation will be done using an
up-and-down sequential method, where the dose of each subsequent patient depends on the
response of the previous patient, called the Biased Coin Design.
The assignment of each subsequent concentration will be based on the response of the previous
patient.As soon as we recruit 45 patients with random dose assignment, we will terminate the
enrollment procedure.
The injectate will be prepared and administered by a research assistant using syringes
connected to the block needle. The operator and the patient will be blinded to the
concentration injected.
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