Osteoarthritis, Knee Clinical Trial
Official title:
Clinical Effects of Autologous Bone Marrow Mononuclear Cell Infusion in Knee Osteoarthritis.
Patients with osteoarthritis, a degenerative joint disease, that meet inclusion criteria
will be allocated into two groups:
- The control group will receive Acetaminophen 750mg orally every 8 hours
- The experimental group will receive Autologous Hematopoietic Stem Cells from bone
marrow (BMASC)
Signed informed consent is required, as well as answering a questionnaire.
Patients in experimental group will receive subcutaneous G-CSF (10ug/kg/day) for 3
consecutive days and, on the 4th day a bone marrow harvest under general sedation will be
performed from posterior iliac crests. The patient will remain in the recovery room while
the cells are processed at the Hematology Service Laboratory. Finally, BMASC will be infused
to the joint under local anesthesia.
The procedure is ambulatory.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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