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Autologous Culture Expanded Adipose Derived MSCs for Treatment of Painful Hip OA

Osteoarthritis, Hip Clinical Trial

Official title:
ASCLEPIOS Autologous Stem CelL Expansion and Prospective Injection for Osteoarthritic Hip Symptoms

Clinical Trial Summary

Will injection(s) of autologous culture-expanded AMSCs be safe and efficacious for treatment of painful Hip OA, and if so, which dosing regimen is most effective?

Clinical Trial Description

This phase I study will enroll 24 subjects with mild to moderate osteoarthritis of the hip. Subjects will receive either a single dose of 30 million autologous culture-expanded adipose-derived mesenchymal stromal cells (AMSCs), or two doses of AMSCs (with one month interval between doses) via ultrasound guided intra-articular hip injection. Patients will be followed for 24 months past their last injection to determine the local and systemic safety of single and two-dose injections of AMSCs in the treatment of symptomatic hip OA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03608579
Study type Interventional
Source Mayo Clinic
Contact
Status Recruiting
Phase Phase 1
Start date November 5, 2018
Completion date December 2024
View Details
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