Clinical Trials Logo
  1. Home
  2. Osteo Arthritis Knee
  3. NCT06231758

Metformin Safety and Efficacy in Osteoarthritis.

Osteo Arthritis Knee Clinical Trial

Official title:
The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Patients With Knee Osteoarthritis

Clinical Trial Summary

Knee osteoarthritis (OA) is a chronic, painful disease associated with considerable morbidity, costs and disability. It is estimated that over a third of people aged over 60 have radiographic knee OA2 and over 50% of these with knee OA will go on to have a total knee replacement in their lifetime. At present there are no licensed treatments that alter disease progress and management is primarily concerned with symptom control to retain or improve joint function, although a trial of strontium ranelate showed promising results.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06231758
Study type Interventional
Source Tanta University
Contact Mostafa Bahaa
Phone +201025538337
Email mbahaa@horus.edu.eg
Status Recruiting
Phase Phase 3
Start date January 30, 2024
Completion date September 20, 2027
View Details
See also
  Status Clinical Trial Phase
Terminated NCT04040985 - Legion Primary Safety and Efficacy N/A
Active, not recruiting NCT04525950 - Robotized Navigation Compared to Conventional Technique in Total Knee Replacement N/A
Recruiting NCT04320914 - High Intensity Laser Therapy (Classes IV) and Ibuprofen Gel Phonophoresis for Treating Knee Osteoarthritis N/A
Completed NCT03886142 - Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis N/A
Terminated NCT04072055 - MOTO Post-marketing Surveillance Study
Not yet recruiting NCT06385275 - The Role of Vitamin K on Knee Osteoarthritis Outcomes Phase 1/Phase 2
Not yet recruiting NCT05290818 - Total Versus Robotic Assisted Unicompartmental Knee Replacement N/A
Withdrawn NCT03271229 - Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee Phase 2
Recruiting NCT05505552 - Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis: N/A
Recruiting NCT05992038 - Use of a Putty as Gap Filler in Open-wedge Osteotomy N/A
Recruiting NCT06066684 - Pain Phenotyping in Knee OA: a Pilot Trial
Completed NCT03847324 - Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty N/A
Recruiting NCT05126485 - Biofeedback Retention in Individuals With AKA Early Phase 1
Completed NCT04956393 - The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study N/A
Recruiting NCT04541342 - Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy N/A
Completed NCT04391842 - Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis Phase 1
Completed NCT03680807 - Power Production in Older Adults With Knee Osteoarthritis
Completed NCT03783455 - Effectiveness of Five Intraarticular Strategies on Knee Osteoarthritis N/A
Not yet recruiting NCT06264362 - Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia N/A
Completed NCT05089253 - Effect of Physical Therapy Modalities in Osteoarthritis N/A