Power Production in Older Adults With Knee Osteoarthritis

Osteo Arthritis Knee Clinical Trial

Official title:

Power Production in Older Adults With Knee Osteoarthritis Compared to Healthy Counterparts

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03680807
• Other study ID #: S60595
• Status: Completed
• Start date: September 1, 2018
• Est. completion date: December 20, 2018

Study information

• Verified date: February 2019
• Source: KU Leuven
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 48
• Est. completion date: December 20, 2018
• Est. primary completion date: December 20, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

Group with knee osteoarthritis:

• Diagnosed with knee osteoarthritis based on RX.

Exclusion Criteria:

Healthy group:

• Systematic engagement in (resistance) exercise in the 12-months prior to participation

• Cardiovascular disease

• Neurological disorders

• Cognitive malfunctioning

• Severe knee or hip problems

Group with knee osteoarthritis:

• Systematic engagement in (resistance) exercise in the 12-months prior to participation

• Cardiovascular disease

• Neurological disorders

• Cognitive malfunctioning

• Severe hip problems

Related Conditions & MeSH terms

• Osteo Arthritis Knee
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Diagnostic Test:
• Muscle function test
Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests

Locations

Country	Name	City	State
Belgium	Department of Movement Sciences	Leuven

Sponsors (1)

Lead Sponsor	Collaborator
KU Leuven

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rate of power development	Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.	up to 3 months
Secondary	Maximal isometric strength	Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer.	up to 3 months
Secondary	Maximal isokinetic strength	Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer.	up to 3 months
Secondary	Stair Climbing performance	Stair ascent duration (in s), the time needed to ascent a flight of stairs.	up to 3 months
Secondary	Gait speed	The average speed to walk 10m as fast as possible (in m/s).	up to 3 months
Secondary	5 repetition sit-to-stand test	The time needed to perform 5 sit-to-stand transitions (in s).	up to 3 months
Secondary	Timed-up-and-go	The time needed to stand up from a chair, walk 3m, turn, walk back and sit down.	up to 3 months
Secondary	Handgrip strength	Handgrip strength (kg) evaluated with Jamar dynamometer.	up to 3 months