The Use of Bone Growth Stimulators for Osteoarthritis of the Knee.

Status Completed

Clinical Trial Summary

The hypothesis of this study is that since osteoarthritis of the knee is primarily a bone disease where the joint changes are secondary, and bone growth stimulators function to decrease intraosseous venous congestion and remodel bone, then there is a potential benefit for the treatment of osteoarthritis of the knee with bone growth stimulators.

Clinical Trial Description

The hypothesis of this study is based on the knowledge that osteoarthritis of the knee is primarily a bone disease, and the joint changes are secondary. Bone growth stimulators function to alleviate intraosseous venous congestion through the process of bone remodeling. The working hypothesis is that alleviation of intraosseous venous congestion leads to improved delivery of nutrition to the tissue to support the health of the bone with improvement in biomechanics leading to clinical improvement. Venous congestion is measured with intraosseous pressure. Additional objective evidence of biomarkers of bone metabolism as well as measurements of subjective questionnaires can provide evidence of benefit. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03476382
Study type	Interventional
Source	Coastal Carolinas Integrated Medicine
Contact
Status	Completed
Phase	N/A
Start date	April 9, 2018
Completion date	November 15, 2018

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04040985` - Legion Primary Safety and Efficacy	N/A
Active, not recruiting	`NCT04525950` - Robotized Navigation Compared to Conventional Technique in Total Knee Replacement	N/A
Recruiting	`NCT04320914` - High Intensity Laser Therapy (Classes IV) and Ibuprofen Gel Phonophoresis for Treating Knee Osteoarthritis	N/A
Completed	`NCT03886142` - Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis	N/A
Terminated	`NCT04072055` - MOTO Post-marketing Surveillance Study
Not yet recruiting	`NCT06385275` - The Role of Vitamin K on Knee Osteoarthritis Outcomes	Phase 1/Phase 2
Not yet recruiting	`NCT05290818` - Total Versus Robotic Assisted Unicompartmental Knee Replacement	N/A
Withdrawn	`NCT03271229` - Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee	Phase 2
Recruiting	`NCT05992038` - Use of a Putty as Gap Filler in Open-wedge Osteotomy	N/A
Recruiting	`NCT05505552` - Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:	N/A
Recruiting	`NCT06066684` - Pain Phenotyping in Knee OA: a Pilot Trial
Completed	`NCT03847324` - Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty	N/A
Recruiting	`NCT05126485` - Biofeedback Retention in Individuals With AKA	Early Phase 1
Completed	`NCT04956393` - The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study	N/A
Recruiting	`NCT04541342` - Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy	N/A
Completed	`NCT04391842` - Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis	Phase 1
Completed	`NCT03680807` - Power Production in Older Adults With Knee Osteoarthritis
Completed	`NCT03783455` - Effectiveness of Five Intraarticular Strategies on Knee Osteoarthritis	N/A
Not yet recruiting	`NCT06264362` - Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia	N/A
Completed	`NCT05089253` - Effect of Physical Therapy Modalities in Osteoarthritis	N/A