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Cartilage Adaptation and Response to Interleukins and Exercise — CARTILEX  

Osteo Arthritis Knee Clinical Trial

Official title:
The Effect of Exercise on the Collagen Synthesis and Cytokine Response in Human Cartilage Tissue With Osteoarthritis

Clinical Trial Summary

This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.

Clinical Trial Description

By using stabile isotope labelling, this study will track the formation and destination of newly formed cartilage collagen in adult humans scheduled for knee replacement surgery due to osteoarthritis. The collagen formation as well as the effect on the cytokine content of the synovial fluid will be examined both at rest and in response to 4 weeks of exercise/training. Overall the project aims to improve the basic understanding of cartilage development and function in relation to osteoarthritis prevention. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03410745
Study type Interventional
Source Bispebjerg Hospital
Contact
Status Completed
Phase N/A
Start date February 21, 2018
Completion date September 10, 2019
View Details
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