OSA Clinical Trial
Official title:
Prospective Study of Efficacy of Sham CPAP vs. Straight CPAP on Cough Intensity in Patients With Chronic Cough
Chronic cough is an important clinical problem in primary care and sub-specialty practice.
Besides the distress experienced by patients with chronic cough, significant healthcare
resources are expended to understand the role of gastroesophageal reflux, asthma and
post-nasal drip in understanding their contribution to cough.
Obstructive sleep apnea (OSA) is common in patients with chronic cough. More importantly,
treatment of OSA with continuous positive airway pressure (CPAP) has led to improvement in
cough for chronic cough patients. Mechanisms by which OSA therapy with CPAP can improve cough
includes beneficial effects on reflux and airway inflammation.
The aim of this study is to definitively establish that CPAP therapy for treatment of OSA in
chronic cough patients improves cough. While these patients with chronic cough are not
routinely screened and treated for OSA, this study aims to evaluate these chronic cough
patients with screening questionnaires for OSA and if necessary with polysomnography and
randomize them to either CPAP or sham CPAP for 6 weeks.
n/a
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