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Clinical Trial Summary

The pain felt after orthopedic surgery in the absence of adequate locoregional anesthesia is often insufficiently controlled, especially during the first 24 hours postoperatively. Methadone, due to its long half-life, may provide better pain control after orthopedic surgery when associated locoregional anesthesia cannot be performed. It may be impossible to perform loco-regional anesthesia in various contexts: patient refusal, pre-existing neurological impairment, infection at the injection site, coagulopathies, inability to cooperate, total language barrier, allergy to anesthetics, unavailability of equipment (ultrasound, etc.) or equipped room, lack of experience of nursing staff in performing the block and in the postoperative management of the patient. Intraoperative administration of methadone in these settings may be superior to sufentanil for pain control during the 24 hours post orthopedic surgery, and the pain control provided by methadone does not appear to imply a higher likelihood of adverse events related to opioids.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05831345
Study type Interventional
Source Brugmann University Hospital
Contact Riccardo Mora, MD
Phone 00393292199132
Email riccardo.mora@chu-brugmann.be
Status Recruiting
Phase Phase 3
Start date February 28, 2023
Completion date December 2024

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