Oropharyngeal Cancer Clinical Trial
Official title:
Evaluation of Functional Results After Surgery of Oropharyngeal Cancers With Soft Palate With Free Flap Reconstruction
The oropharynx is a complex anatomical structure necessary for nasal breathing, swallowing
and phonation. The removal of oropharyngeal cancers can lead to sequelae, particularly in the
case of resections affecting the soft palate. The main sequelae are represented by rhinolalia
and swallowing disorders with nasal regurgitation.
The treatment of oropharyngeal tumors is based on primary surgery or radiotherapy, but tumors
of the soft palate are often treated by radiotherapy or radio-chemotherapy first. Surgery is
often kept for relapses, because it is considered to lead to important sequelae. However,
chemoradiotherapy of the oropharynx is also responsible for acute toxicities, and late
sequelae can be frequent and important.
Recent publications tend to show that primary surgery would give better survival rates
compared to radiotherapy, particularly in advanced stages, including viro-induced cancers. In
addition, primary surgery can reduce the dose of radiation delivered to the oropharynx and
thus reduce its long-term toxicity.
It is currently possible to reconstruct a loss of substance after surgery of oropharyngeal
cancers, including the soft palate by using free flaps, limiting the postoperative sequelae
usually observed without reconstruction.
There is little data on reconstructions of the soft palate, their sequelae and their impact
on the quality of life.
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