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Clinical Trial Summary

The long-term goal is to test the clinical efficacy of senolytic therapies to reduce progression to and severity of sepsis in older patients. The central hypothesis is that a threshold burden of SnCs predisposes to a SASP mediated dysfunctional response to PAMPs, contributing to a disproportionate burden of sepsis in older patients. The study hypothesizes timely treatment with fisetin will interrupt this pathway. A multicenter, randomized, adaptive allocation clinical trial to identify the most efficacious dose of the senolytic fisetin to reduce the composite cardiovascular, respiratory, and renal sequential organ failure assessment score at 1 week, and predict the probability of success of a definitive phase III clinical trial.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05758246
Study type Interventional
Source University of Minnesota
Contact Michael Puskarich, MD
Phone 612 626 6911
Email mike-em@umn.edu
Status Recruiting
Phase Phase 2
Start date August 23, 2023
Completion date August 23, 2026

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