Oral Glucose Tolerance Test Clinical Trial
Official title:
Effects of Fluid Milk in Attenuating Hyperglycemia and Hypertriglyceridemia After Meal
Epidemiological studies indicate that risk of type 2 diabetes is lower when milk is consumed in the regular diet. Milk products are unique in that they produce high insulin response despite their low glycemic index. The general aim of the proposed study is to determine the effect of fluid milk on attenuating the postprandial surge in plasma glucose and triglyceride after meals and its associated physiological mechanisms. The investigators hypothesize that the consumption of one or two servings of non-fat milk added to a standard oral glucose tolerance test (OGTT) solution or the high fat tolerance test meal will attenuate postprandial hyperglycemia and triglyceridemia. The investigators hypothesize that the postulated improvement in postprandial metabolic response due to the consumption of fluid milk will be associated with increased postprandial insulin secretion as well as insulin-mediated endothelial vasodilation and whole-limb perfusion.
Status | Completed |
Enrollment | 30 |
Est. completion date | December 2015 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 20 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Apparently health, sedentary. All subjects will have a BMI of 25-35 kg/m2. Exclusion Criteria: - Candidates who are taking cardiovascular-acting drugs will not be eligible for participation. Subjects with significant intima-media thickening, plaque formation, characteristics of atherosclerosis, metabolic diseases, gastrointestinal disorders, and/or renal disease will be excluded from the study. Additional exclusion criteria will be cow milk allergy or lactose intolerance, pregnancy or lactation, and alcohol abuse. |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | Cardiovascular Aging Research Laboratory | Austin | Texas |
Lead Sponsor | Collaborator |
---|---|
University of Texas at Austin | Dairy Research Institute |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | insulin | 2-4 hour postprandially | Yes | |
Other | glucagon | 2-4 hour postprandially | Yes | |
Other | GIP | 2-4 hour postprandially | Yes | |
Other | GLP | 2-4 hour postprandially | Yes | |
Primary | blood glucose | 2 hour postprandially | Yes | |
Primary | plasma triglyceride | 4 hour postprandially | Yes | |
Secondary | femoral artery blood flow | 2-4 hour postprandially | No | |
Secondary | brachial artery flow-mediated dilation | 2-4 hour postprandially | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
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