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Clinical Trial Summary

Evidence regarding the role of early (<24 hours) antithrombotics post-revascularization with either intravenous thrombolysis (IVT), endovascular thrombectomy (EVT), or a combination of both remains scarce. In 2018 the American Heart Association/American Stroke Association changed their recommendation, stating that the risk of antithrombotic therapy within the first 24 hours after treatment with IVT (with or without EVT) is uncertain. This was changed after data emerged that early antithrombotics may be safe and may improve outcomes in select patients undergoing EVT.

Recently the investigators showed for the first time that significant residual basilar thrombus can exist after EVT despite complete angiographic revascularization using endovascular optical coherence tomography imaging. This residual thrombus could cause ongoing function-limiting strokes with occlusion of vital basilar perforators after EVT. Therefore, the investigators propose a prospective,non-randomized safety study to evaluate optical coherence tomography guided antithrombotic management for patients with confirmed residual thrombus after EVT for basilar occlusion.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04121611
Study type Interventional
Source Sunnybrook Health Sciences Centre
Contact Christopher R Pasarikovski, MD
Phone 647-550-0862
Email chris.pasarikovski@mail.utoronto.ca
Status Recruiting
Phase N/A
Start date October 14, 2019
Completion date December 14, 2021

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