Optic Neuropathy in 10 Patients With Glioblastoma Receiving Bevacizumab

Status Withdrawn

Clinical Trial Summary

Does treatment with bevacizumab (Avastin) in combination with prior or current radiotherapy lead to optic neuropathy?

Clinical Trial Description

The investigators research will focus on patients prior to them beginning treatment with bevacizumab (Avastin), by undergoing a baseline visual examination with Visual evoked Potentials testing. This will allow testing of the patient's optic nerve function bilaterally. Patients will then begin their normally scheduled treatment with avastin, and other chemotherapeutic agents, as well any radiation treatments scheduled. Once patients have completed their treatment with avastin for 6-8 weeks, they will then undergo their second Visual Evoked Potential testing, with both studies then being compared for any changes within the optic nerves. Patients will also be recommended to have stringent follow up with an Ophthalmologist to include confrontational visual field testing, external and anterior segment examination, and dilated fundus examination. The investigators main objective is to assess whether or not bevacizumab causes a direct toxic effect on patient's optic nerves leading to an acute/subacute optic neuropathy. ;

Study Design

Related Conditions & MeSH terms

Glioblastoma
Optic Nerve Diseases
Optic Neuropathy
Peripheral Nervous System Diseases

Clinical Trial Details

NCT number	NCT01331616
Study type	Interventional
Source	West Penn Allegheny Health System
Contact
Status	Withdrawn
Phase	Early Phase 1
Start date	March 2011
Completion date	July 2012

View Details

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