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Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section — PPAP C-Section  

Opioid Use Clinical Trial

Official title:
Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

Clinical Trial Summary

The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants

Clinical Trial Description

The approach includes 1) development and implementation of an innovative PPAP infrastructure at participating CTSA hubs (Aim 1) and 2) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids and precision dosing in nursing mothers and infants (Aim 2). SPECIFIC AIMS: The purpose of this collaborative CTSA application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in Aim 1. Develop and implement a perioperative precision analgesia platform (PPAP) by linking genomics to opioid metabolism, Clinical Pharmacogenetics Implementation (CPIC) guidelines, precision dosing, clinical safety, and personalizing analgesia Aim 2. Evaluate utility of PPAP in nursing mothers and their newborns following Cesarean Section The investigators hypothesize that CYP2D6 and other (ABCB1, and OPRM1) variants will explain clinical and pharmacokinetic variations of oxycodone, and PPAP implementation will reduce adverse effects in mothers and infants. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05380531
Study type Interventional
Source University of Pittsburgh
Contact Senthilkumar Sadhasivam, MD, MPH
Phone 4126472994
Email sadhasivams@upmc.edu
Status Recruiting
Phase N/A
Start date December 5, 2022
Completion date October 30, 2026
View Details
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