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Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.

Opioid Use Clinical Trial

Official title:
Effect of Fentanyl on Expression of Main Opioid Receptor (OPRM1) on Human Granulosa Cells During Ultrasound-guided Transvaginal Oocyte Retrieval.

Clinical Trial Summary

Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (OPRM1) is present on human granulosa cells and exogenous opiates and their antagonists can influence granulosa cell vascular endothelial growth factor (VEGF) production via OPRM1, causing ovarian hyperstimulation syndrome.

This study aims to investigate if a single exposure to opioids is enough to produce activation of stress mechanism during oocyte retrieval.

Clinical Trial Description

The main opioid receptor (OPRM1) is present on human granulosa cells and exogenous opiates and their antagonists can influence granulosa cell vascular endothelial growth factor (VEGF) production via OPRM1, causing ovarian hyperstimulation syndrome.

This study aims to investigate if a single exposure to opioids is enough to produce activation of stress mechanism during ultrasound-guided oocyte retrieval. It will be measured the level of cortisone before and 15min after iv administration of fentanyl on blood and on oocyte fluid. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03248076
Study type Observational
Source George Papanicolaou Hospital
Contact Irene Asouhidou, MD, PhD
Phone 00302310999321
Email iasouh@aol.com
Status Recruiting
Phase N/A
Start date April 1, 2017
Completion date October 10, 2018
View Details
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