Opioid-use Disorder Clinical Trial
Official title:
A Prospective, Randomized Trial of the Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post-Operative Opioid Use Disorder Symptoms
The purpose of this research study is to compare two ways of managing pain in people who are
taking buprenorphine and are scheduled to undergo surgery. Buprenorphine (subutex) and
buprenorphine/naloxone (suboxone) are effective long-term treatments for substance use
disorders. The management of pain after surgery in adults taking buprenorphine can be
challenging, as buprenorphine may interfere with the effectiveness of other medications used
to treat pain.
We want to compare how well pain is managed after surgery ("post-op") in two groups:
The "Continue Group": those who continue taking their standard dose of buprenorphine before,
during and after surgery.
The "Reduce Group": those who are placed on a lower dose of buprenorphine starting one day
before surgery and during the time period after surgery until the pain from the surgery has
decreased. Once the pain from the surgery has decreased, you will be put back on your full
dose of buprenorphine.
We also want to find out if there is a difference in pain, opioid cravings, and relapse rates
in the month following surgery.
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